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GAMMAGARD LIQUID is a ready-to-use liquid medicine that contains immunoglobulin (Ig), which help to protect the body against infection. These antibodies, collected from healthy people, replace the missing antibodies in people with primary immunodeficiency (PI).1

GAMMAGARD LIQUID temporarily increases the amount of antibodies in your body to fight bacteria and viral agents.2

Two Routes of Administration

GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% offers a choice of intravenous (IV) and subcutaneous (SubQ) administration options. Ig can be infused either directly into a vein (IV) or under the skin into the fatty tissue (SubQ) in patients 2 years and older with PI.2 Talk to your doctor about the treatment administration options that work best for you and your lifestyle.

Intravenous (IV)2 Administration Location Infused directly into the bloodstream through a vein Frequency* Once every 3-4 weeks Number of Sites One Who Administers A doctor, nurse, or other healthcare professional Where Ig is Administered At a hospital or clinic or at home with nurse present
Subcutaneous (SubQ)2 Administration Location Infused under the skin in the fatty tissues of the abdomen, thigh, upper arm, or lower back Frequency* Once a week Number of Sites Dose can be given simultaneously in multiple sites, not to exceed 8 Who Administers Can be self-administered after patient is trained by a healthcare professional Where Ig is Administered At home after being trained

*Based on clinical response

†Can also be administered by a caregiver

Visit to learn more about GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10%.

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  • My Infusion Log & Wellness Calendar
    My Infusion Log & Wellness Calendar

    Stay on top of your Ig treatment and overall wellness by logging your infusions after every treatment, tracking your daily health, and communicating this information to your healthcare team.

We've got eligible patients with Primary Immunodeficiency (PI) covered!

Learn more about the MyIgCopayCard Program here.


Detailed Important Safety Information

Please read below for Indication and Detailed Important Safety Information for GAMMAGARD LIQUID. Please see Full Prescribing Information and Patient Product Information, including Boxed Warning.

GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% Solution


  • GAMMAGARD LIQUID is indicated for the treatment of primary humoral immunodeficiency diseases (PI) in patients two years of age and older. GAMMAGARD LIQUID is a ready-to-use, liquid medicine that contains immunoglobulin G (IgG) antibodies, which protect the body against infection.
  • GAMMAGARD LIQUID is made from human plasma that is donated by healthy people and contains antibodies that replace the missing antibodies in patients with PI.
  • GAMMAGARD LIQUID is given into a vein (intravenously) or under the skin (subcutaneously). You and your healthcare provider will decide which way is best for you. Most of the time infusions under the skin are given at home by patients or caregivers. Although it is possible to give yourself infusions into a vein at home, they are more often given in a hospital or infusion center by a nurse. Only use GAMMAGARD LIQUID by yourself after you have been instructed by your healthcare provider.

Important Safety Information

What is the most important information that I should know about GAMMAGARD LIQUID?

GAMMAGARD LIQUID can cause the following serious reactions:

  • Severe allergic reactions causing difficulty in breathing or skin rashes
  • Decreased kidney function or kidney failure
  • Blood clots in the heart, brain, lungs or elsewhere in the body
  • Severe headache, drowsiness, fever, painful eye movements, or nausea and vomiting
  • Dark colored urine, swelling, fatigue, or difficulty breathing

Who should not use GAMMAGARD LIQUID?

Do not use GAMMAGARD LIQUID if you:

  • Have a known history of a severe allergic reaction to IgG or other blood products.
  • Have selective (or severe) immunoglobulin A (IgA) deficiency with antibodies to IgA

GAMMAGARD LIQUID can cause serious side effects. Call your healthcare professional or go to the emergency department right away if you get:

  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
  • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation of the lining around your brain.
  • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
  • Pain, swelling, warmth, redness, or a lump in your legs or arms. These could be signs of a blood clot.
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
  • Chest pain or trouble breathing, or blue lips or extremities. These could be signs of a serious heart or lung problem.
  • Fever over 100°F. This could be a sign of an infection.

Whenever giving yourself treatments at home, you should have another responsible person present to help treat side effects or get help if you have a serious adverse reaction occur. Ask your healthcare provider whether you should have rescue medications available, such as antihistamines or epinephrine.

What are the possible or reasonably likely side effects of GAMMAGARD LIQUID for PI?

The following one or more possible reactions may occur at the site of infusion. These generally go away within a few hours, and are less likely after the first few infusions: Mild or moderate pain, swelling, itching, redness, bruising, and warmth.

During the infusion of GAMMAGARD LIQUID, look out for the first signs of the following common side effects: Headache, migraine, fever, fatigue, itching, rash/hives, cough, chest pain/tightness, chills/shaking chills, dizziness, nausea/vomiting, faster heart rate, upper abdominal pain, increased blood pressure, muscle cramps, and sore throat.

These are not all the possible side effects. Talk to your healthcare professional about any side effects that bother you or that don't go away.

You are encouraged to report suspected side effects by contacting FDA at 1-800-FDA-1088 or or Shire at 1-800-999-1785.

The risk information provided here is not comprehensive. To learn more, talk about GAMMAGARD LIQUID with your healthcare provider or pharmacist.

Please see the FDA-Approved Patient Product Labeling.


  1. Blaese RM, Bonilla FA, Stiehm ER, Younger ME, eds. Patient & Family Handbook for Primary Immunodeficiency Diseases. 5th ed. Towson, MD: Immune Deficiency Foundation; 2013.
  2. GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% [Prescribing Information]. Westlake Village, CA: Baxalta US Inc.